ICARS made great strides in 2021 including establishing itself as a self-governing organisation, building a diverse portfolio of projects across Latin America, Asia, and Africa, and advocating for intervention and implementation research to tackle antimicrobial resistance (AMR) at multiple high-level events. The 2021 annual report presents ICARS’ key achievements across four strategic pillars: testing solutions, translating evidence, advocacy, and capability building. The report also shares governance and organisational updates, financial statements and introduces the core team, Board of Directors and Technical Advisory Forum.